Tablet Presentation

Each film coated tablet contains:
Leflunomide IP 10/20 mg

Leflunomide belongs to the class of drugs i.e disease modifying anti-rheumatoid drugs. It has immune suppressive properties and is the inhibitor of the pyrimidine synthesis.

Therapeutic Indication

Treats rheumatoid arthritis

Mechanism of Action

Leflunomide is a prodrug which is firstly converted to its active metabolite. It inhibits the auto –immune T- cell proliferation, production of auto antibodies by the B cells, decreases the dNA and rNA synthesis.

Pharmacokinetics

Absorption: It is absorbed by oral route of administration
Protein binding: It is 99.3% bound to plasma proteins
Metabolism: It is metabolized in the liver to its active metabolite
Excretion: It is excreted via urine

Side Effects

• Nausea
• Headache
• Diarrhea
• Abdominal pain
• Back pain
• Rashes
• High blood pressure
• Weakness

Contraindications

• Contraindicated in people with known hypersensitivity
• Contraindicated in pregnancy